TF JASPAR ID Class Family Tax Group IC GC Content Target region hits Target region non-hits Background region hits Background region non-hits Target TFBS hits Target TFBS nucleotide rate Background TFBS hits Background TFBS nucleotide rate Z-score Fisher score ZNF740 MA0753.1 C2H2 zinc finger factors Other factors with up to three adjacent zinc fingers vertebrates 12.467 0.786 1430 250 1201 479 4631 0.025 3390 0.018 67.947 49.336 ZNF263 MA0528.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 16.073 0.597 1393 287 1164 516 4081 0.046 2501 0.028 146.772 46.149 Ascl2 MA0816.1 Basic helix-loop-helix factors (bHLH) MyoD / ASC-related factors vertebrates 12.850 0.580 1206 474 1005 675 2263 0.012 1667 0.009 46.312 29.475 REST MA0138.2 C2H2 zinc finger factors Factors with multiple dispersed zinc fingers vertebrates 23.134 0.596 58 1622 8 1672 61 0.001 8 0.000 85.815 23.508 INSM1 MA0155.1 C2H2 zinc finger factors Factors with multiple dispersed zinc fingers vertebrates 14.862 0.667 1102 578 921 759 1954 0.013 1561 0.010 34.574 22.962 RFX5 MA0510.2 Fork head / winged helix factors RFX-related factors vertebrates 20.460 0.515 110 1570 37 1643 122 0.001 38 0.000 54.476 21.969 MSC MA0665.1 Basic helix-loop-helix factors (bHLH) Tal-related factors vertebrates 14.856 0.452 408 1272 266 1414 470 0.003 299 0.002 31.263 21.309 Myod1 MA0499.1 Basic helix-loop-helix factors (bHLH) MyoD / ASC-related factors vertebrates 13.102 0.600 1616 64 1534 146 6119 0.043 4963 0.035 60.120 19.774 KLF16 MA0741.1 C2H2 zinc finger factors Three-zinc finger Krüppel-related factors vertebrates 13.161 0.767 1545 135 1439 241 7737 0.046 6301 0.038 61.049 19.401 RREB1 MA0073.1 C2H2 zinc finger factors Factors with multiple dispersed zinc fingers vertebrates 22.278 0.623 289 1391 178 1502 328 0.004 206 0.002 38.018 17.821 RFX2 MA0600.2 Fork head / winged helix factors RFX-related factors vertebrates 20.246 0.536 128 1552 56 1624 139 0.001 60 0.001 40.771 17.487 E2F4 MA0470.1 Fork head / winged helix factors E2F-related factors vertebrates 13.176 0.729 1534 146 1432 248 10505 0.063 8943 0.053 56.174 17.450 Tcf12 MA0521.1 Basic helix-loop-helix factors (bHLH) E2A-related factors vertebrates 13.159 0.597 1574 106 1484 196 5132 0.031 4068 0.024 55.922 17.237 Gata4 MA0482.1 Other C4 zinc finger-type factors GATA-type zinc fingers vertebrates 13.320 0.388 1255 425 1124 556 2938 0.017 2402 0.014 36.466 14.745 RFX3 MA0798.1 Fork head / winged helix factors RFX-related factors vertebrates 16.894 0.507 174 1506 96 1584 194 0.002 103 0.001 35.849 14.636 TFAP2C MA0524.2 Basic helix-span-helix factors (bHSH) AP-2 vertebrates 10.460 0.738 1546 134 1464 216 7440 0.048 6812 0.044 26.850 13.030 SP8 MA0747.1 C2H2 zinc finger factors Three-zinc finger Krüppel-related factors vertebrates 12.140 0.714 1501 179 1410 270 5299 0.034 4552 0.030 38.840 12.953 SP3 MA0746.1 C2H2 zinc finger factors Three-zinc finger Krüppel-related factors vertebrates 10.325 0.709 1603 77 1537 143 10087 0.060 8412 0.050 62.023 12.893 TFAP2B MA0811.1 Basic helix-span-helix factors (bHSH) AP-2 vertebrates 10.870 0.738 1556 124 1478 202 8178 0.053 7453 0.048 29.705 12.622 Myog MA0500.1 Basic helix-loop-helix factors (bHLH) MyoD / ASC-related factors vertebrates 13.109 0.621 1631 49 1580 100 7437 0.044 5996 0.036 62.746 11.344 RFX4 MA0799.1 Fork head / winged helix factors RFX-related factors vertebrates 15.596 0.481 247 1433 169 1511 275 0.002 186 0.002 26.091 10.542 Rfx1 MA0509.1 Fork head / winged helix factors RFX-related factors vertebrates 15.161 0.557 337 1343 248 1432 385 0.003 279 0.002 23.735 10.400 MZF1(var.2) MA0057.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 9.400 0.588 1628 52 1579 101 7855 0.043 5805 0.031 86.349 10.370 TFAP4 MA0691.1 Basic helix-loop-helix factors (bHLH) bHLH-ZIP factors vertebrates 14.151 0.444 654 1026 542 1138 860 0.005 690 0.004 20.464 10.366 EGR3 MA0732.1 C2H2 zinc finger factors Three-zinc finger Krüppel-related factors vertebrates 18.153 0.721 652 1028 542 1138 920 0.007 766 0.006 21.570 10.070 EBF1 MA0154.3 Rel homology region (RHR) factors Early B-Cell Factor-related factors vertebrates 16.027 0.559 347 1333 262 1418 401 0.003 304 0.002 20.805 9.399 NRF1 MA0506.1 Basic leucine zipper factors (bZIP) Jun-related factors vertebrates 14.300 0.810 1440 240 1359 321 8740 0.052 7604 0.045 44.104 9.157 Pparg::Rxra MA0065.2 Nuclear receptors with C4 zinc fingers::Nuclear receptors with C4 zinc fingers Thyroid hormone receptor-related factors (NR1)::RXR-related receptors (NR2) vertebrates 11.663 0.547 591 1089 490 1190 763 0.006 594 0.005 26.877 9.115 NHLH1 MA0048.2 Basic helix-loop-helix factors (bHLH) Tal-related factors vertebrates 13.190 0.691 1231 449 1134 546 2512 0.014 2190 0.012 21.828 8.860 ZIC3 MA0697.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 17.252 0.750 372 1308 291 1389 450 0.004 352 0.003 20.222 8.258 ZIC1 MA0696.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 18.774 0.762 654 1026 557 1123 904 0.007 772 0.006 17.782 8.182 EGR2 MA0472.2 C2H2 zinc finger factors Three-zinc finger Krüppel-related factors vertebrates 15.289 0.730 990 690 890 790 1918 0.011 1788 0.011 10.195 8.147 SP2 MA0516.1 C2H2 zinc finger factors Three-zinc finger Krüppel-related factors vertebrates 13.721 0.768 1565 115 1509 171 10059 0.082 8251 0.067 79.663 8.029 GLIS2 MA0736.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 16.871 0.758 513 1167 427 1253 666 0.005 568 0.004 15.378 7.522 Klf4 MA0039.2 C2H2 zinc finger factors Three-zinc finger Krüppel-related factors vertebrates 12.618 0.771 1629 51 1591 89 12769 0.069 11118 0.060 50.942 7.321 GCM2 MA0767.1 GCM domain factors GCM factors vertebrates 11.005 0.594 1274 406 1191 489 2656 0.014 2294 0.012 23.988 7.289 EGR1 MA0162.2 C2H2 zinc finger factors Three-zinc finger Krüppel-related factors vertebrates 13.889 0.785 1625 55 1588 92 14393 0.109 12137 0.092 80.239 6.772 NR2C2 MA0504.1 Nuclear receptors with C4 zinc fingers RXR-related receptors (NR2) vertebrates 16.248 0.589 744 936 657 1023 1045 0.008 894 0.007 19.581 6.640 Bhlha15 MA0607.1 Basic helix-loop-helix factors (bHLH) Tal-related factors vertebrates 11.820 0.455 1218 462 1138 542 2365 0.010 2224 0.010 8.444 6.537 GCM1 MA0646.1 GCM domain factors GCM factors vertebrates 13.024 0.596 989 691 903 777 1572 0.009 1431 0.009 12.364 6.467 TEAD1 MA0090.2 TEA domain factors TEF-1-related factors vertebrates 9.508 0.424 1508 172 1452 228 4527 0.025 4236 0.023 14.224 6.392 TFAP2A(var.2) MA0810.1 Basic helix-span-helix factors (bHSH) AP-2 vertebrates 10.759 0.764 1601 79 1561 119 14051 0.091 12714 0.083 42.729 6.172 ZBTB7B MA0694.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 13.963 0.628 788 892 711 969 1157 0.008 1027 0.007 14.052 5.480 TFAP2A(var.3) MA0872.1 Basic helix-span-helix factors (bHSH) AP-2 vertebrates 14.096 0.784 1018 662 946 734 1864 0.013 1774 0.012 7.693 5.042 Sox6 MA0515.1 High-mobility group (HMG) domain factors SOX-related factors vertebrates 13.201 0.401 1306 374 1247 433 2958 0.016 2919 0.016 2.236 4.649 TCF3 MA0522.2 Basic helix-loop-helix factors (bHLH) E2A-related factors vertebrates 11.473 0.608 1640 40 1616 64 6479 0.035 6200 0.034 11.303 4.531 PRDM1 MA0508.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 15.223 0.380 467 1213 409 1271 622 0.005 488 0.004 23.499 4.379 ZBTB7C MA0695.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 10.450 0.618 1076 604 1013 667 1976 0.013 1809 0.012 13.623 4.291 Ar MA0007.3 Nuclear receptors with C4 zinc fingers Steroid hormone receptors (NR3) vertebrates 18.664 0.539 53 1627 32 1648 53 0.000 34 0.000 13.405 4.289 KLF14 MA0740.1 C2H2 zinc finger factors Three-zinc finger Krüppel-related factors vertebrates 16.072 0.661 931 749 867 813 1593 0.012 1557 0.012 3.376 4.223 EWSR1-FLI1 MA0149.1 Tryptophan cluster factors Ets-related factors vertebrates 32.871 0.554 29 1651 14 1666 34 0.000 24 0.000 8.628 4.184 TCF4 MA0830.1 Basic helix-loop-helix factors (bHLH) E2A-related factors vertebrates 11.920 0.625 1649 31 1629 51 7338 0.040 6851 0.037 18.860 4.103 FIGLA MA0820.1 Basic helix-loop-helix factors (bHLH) Tal-related factors vertebrates 10.386 0.566 1517 163 1479 201 4218 0.023 4028 0.022 9.495 3.915 SMAD2::SMAD3::SMAD4 MA0513.1 SMAD/NF-1 DNA-binding domain factors::SMAD/NF-1 DNA-binding domain factors::SMAD/NF-1 DNA-binding domain factors SMAD factors::SMAD factors::SMAD factors vertebrates 13.704 0.556 586 1094 529 1151 757 0.005 704 0.005 7.179 3.908 ZIC4 MA0751.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 13.598 0.697 896 784 837 843 1582 0.013 1395 0.011 19.442 3.789 SCRT1 MA0743.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 17.728 0.573 119 1561 90 1590 123 0.001 92 0.001 12.493 3.788 NFYB MA0502.1 Heteromeric CCAAT-binding factors Heteromeric CCAAT-binding factors vertebrates 14.488 0.501 471 1209 419 1261 625 0.005 598 0.005 4.246 3.769 NFYA MA0060.2 Heteromeric CCAAT-binding factors Heteromeric CCAAT-binding factors vertebrates 16.655 0.516 191 1489 155 1525 210 0.002 208 0.002 0.559 3.754 TFAP2C(var.3) MA0815.1 Basic helix-span-helix factors (bHSH) AP-2 vertebrates 14.479 0.780 1089 591 1033 647 2222 0.016 2122 0.015 7.821 3.706 TAL1::TCF3 MA0091.1 Basic helix-loop-helix factors (bHLH)::Basic helix-loop-helix factors (bHLH) Tal-related factors::E2A-related factors vertebrates 14.070 0.453 371 1309 324 1356 439 0.003 389 0.003 8.759 3.688 GATA3 MA0037.2 Other C4 zinc finger-type factors GATA-type zinc fingers vertebrates 13.796 0.265 1253 427 1203 477 3350 0.015 3250 0.014 4.934 3.565 Myb MA0100.2 Tryptophan cluster factors Myb/SANT domain factors vertebrates 13.365 0.452 1191 489 1140 540 2412 0.013 2227 0.012 12.413 3.486 TEAD4 MA0809.1 TEA domain factors TEF-1-related factors vertebrates 9.386 0.418 1422 258 1381 299 4156 0.023 4073 0.022 4.082 3.451 TBX5 MA0807.1 T-Box factors TBX2-related factors vertebrates 8.477 0.507 1570 110 1541 139 4990 0.022 5086 0.022 -3.925 3.427 Tcf21 MA0832.1 Basic helix-loop-helix factors (bHLH) Tal-related factors vertebrates 18.108 0.461 72 1608 51 1629 72 0.001 52 0.000 10.349 3.415 JDP2(var.2) MA0656.1 Basic leucine zipper factors (bZIP) Fos-related factors vertebrates 17.511 0.485 187 1493 154 1526 211 0.001 166 0.001 12.076 3.390 ZEB1 MA0103.2 Homeo domain factors HD-ZF factors vertebrates 13.264 0.621 1451 229 1413 267 3571 0.017 3515 0.017 2.790 3.326 EGR4 MA0733.1 C2H2 zinc finger factors Three-zinc finger Krüppel-related factors vertebrates 13.890 0.635 446 1234 400 1280 574 0.005 505 0.004 12.269 3.302 Hand1::Tcf3 MA0092.1 Basic helix-loop-helix factors (bHLH)::Basic helix-loop-helix factors (bHLH) Tal-related factors::E2A-related factors vertebrates 10.144 0.507 1260 420 1215 465 2546 0.014 2464 0.013 5.198 3.161 Crx MA0467.1 Homeo domain factors Paired-related HD factors vertebrates 12.929 0.404 734 946 684 996 1019 0.006 982 0.006 3.884 3.136 Nr2e3 MA0164.1 Nuclear receptors with C4 zinc fingers RXR-related receptors (NR2) vertebrates 12.028 0.373 358 1322 318 1362 431 0.002 363 0.001 9.420 3.066 SP1 MA0079.3 C2H2 zinc finger factors Three-zinc finger Krüppel-related factors vertebrates 13.323 0.810 1650 30 1635 45 18245 0.109 15228 0.091 84.865 2.981 RELA MA0107.1 Rel homology region (RHR) factors NF-kappaB-related factors vertebrates 14.757 0.567 611 1069 566 1114 762 0.004 716 0.004 5.409 2.886 SCRT2 MA0744.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 17.902 0.568 174 1506 146 1534 185 0.001 149 0.001 10.610 2.878 Gata1 MA0035.3 Other C4 zinc finger-type factors GATA-type zinc fingers vertebrates 13.597 0.352 729 951 684 996 1176 0.007 1046 0.006 13.327 2.780 GATA1::TAL1 MA0140.2 Other C4 zinc finger-type factors::Basic helix-loop-helix factors (bHLH) GATA-type zinc fingers::Tal-related factors vertebrates 14.296 0.444 196 1484 168 1512 217 0.002 188 0.002 8.950 2.704 Sox2 MA0143.3 High-mobility group (HMG) domain factors SOX-related factors vertebrates 13.532 0.436 1492 188 1463 217 4337 0.019 4118 0.018 9.669 2.675 CREB3L1 MA0839.1 Basic leucine zipper factors (bZIP) CREB-related factors vertebrates 17.262 0.560 47 1633 33 1647 47 0.000 34 0.000 8.311 2.653 NR3C2 MA0727.1 Nuclear receptors with C4 zinc fingers Steroid hormone receptors (NR3) vertebrates 18.985 0.510 70 1610 53 1627 70 0.001 59 0.001 5.878 2.650 Znf423 MA0116.1 C2H2 zinc finger factors Factors with multiple dispersed zinc fingers vertebrates 17.925 0.679 737 943 695 985 1032 0.008 953 0.008 9.901 2.573 NFKB1 MA0105.4 Rel homology region (RHR) factors NF-kappaB-related factors vertebrates 20.522 0.671 154 1526 130 1550 163 0.001 147 0.001 4.733 2.566 GATA2 MA0036.2 Other C4 zinc finger-type factors GATA-type zinc fingers vertebrates 13.428 0.361 556 1124 518 1162 773 0.006 725 0.005 6.646 2.459 KLF5 MA0599.1 C2H2 zinc finger factors Three-zinc finger Krüppel-related factors vertebrates 12.860 0.792 1667 13 1658 22 23531 0.127 19945 0.108 84.832 2.446 NR3C1 MA0113.3 Nuclear receptors with C4 zinc fingers Steroid hormone receptors (NR3) vertebrates 19.181 0.483 66 1614 51 1629 66 0.001 57 0.001 4.888 2.367 MEIS2 MA0774.1 Homeo domain factors TALE-type homeo domain factors vertebrates 10.958 0.494 1278 402 1245 435 2726 0.012 2525 0.011 11.319 2.294 TFAP2B(var.3) MA0813.1 Basic helix-span-helix factors (bHSH) AP-2 vertebrates 14.355 0.726 1047 633 1010 670 1977 0.014 1904 0.013 6.012 2.290 PLAG1 MA0163.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 19.352 0.798 337 1343 307 1373 396 0.003 346 0.003 10.037 2.284 E2F6 MA0471.1 Fork head / winged helix factors E2F-related factors vertebrates 13.338 0.693 1639 41 1626 54 11433 0.068 9765 0.058 57.553 2.247 FOXH1 MA0479.1 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 13.762 0.401 847 833 810 870 1387 0.008 1378 0.008 0.759 2.234 Klf1 MA0493.1 C2H2 zinc finger factors Three-zinc finger Krüppel-related factors vertebrates 13.595 0.665 1438 242 1412 268 4361 0.026 4119 0.025 12.580 2.166 HNF4G MA0484.1 Nuclear receptors with C4 zinc fingers RXR-related receptors (NR2) vertebrates 13.379 0.492 1013 667 979 701 1620 0.013 1535 0.012 8.396 2.093 MEIS3 MA0775.1 Homeo domain factors TALE-type homeo domain factors vertebrates 9.016 0.490 1629 51 1616 64 6606 0.029 6833 0.030 -7.971 2.061 ZBTB33 MA0527.1 C2H2 zinc finger factors Other factors with up to three adjacent zinc fingers vertebrates 14.336 0.609 311 1369 286 1394 359 0.003 355 0.003 0.790 1.971 Bcl6 MA0463.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 13.663 0.433 389 1291 362 1318 450 0.003 419 0.003 5.640 1.960 MYF6 MA0667.1 Basic helix-loop-helix factors (bHLH) MyoD / ASC-related factors vertebrates 14.583 0.392 355 1325 329 1351 415 0.002 371 0.002 7.200 1.952 Pou5f1::Sox2 MA0142.1 Homeo domain factors::High-mobility group (HMG) domain factors POU domain factors::SOX-related factors vertebrates 14.808 0.308 102 1578 87 1593 109 0.001 96 0.001 5.113 1.916 ID4 MA0824.1 Basic helix-loop-helix factors (bHLH) HLH domain only vertebrates 11.591 0.601 1542 138 1524 156 4557 0.025 4472 0.024 3.989 1.899 Atoh1 MA0461.2 Basic helix-loop-helix factors (bHLH) Tal-related factors vertebrates 11.381 0.409 754 926 724 956 1102 0.006 1128 0.006 -2.498 1.853 ELK4 MA0076.2 Tryptophan cluster factors Ets-related factors vertebrates 13.085 0.630 1296 384 1271 409 2501 0.015 2812 0.017 -19.680 1.803 SRF MA0083.3 MADS box factors Responders to external signals (SRF/RLM1) vertebrates 20.984 0.467 11 1669 6 1674 11 0.000 6 0.000 8.109 1.799 RXRG MA0856.1 Nuclear receptors with C4 zinc fingers RXR-related receptors (NR2) vertebrates 22.332 0.505 97 1583 84 1596 102 0.001 90 0.001 4.707 1.717 Sox11 MA0869.1 High-mobility group (HMG) domain factors SOX-related factors vertebrates 27.229 0.305 8 1672 4 1676 8 0.000 4 0.000 7.677 1.643 RXRB MA0855.1 Nuclear receptors with C4 zinc fingers RXR-related receptors (NR2) vertebrates 23.110 0.505 49 1631 40 1640 50 0.000 42 0.000 4.589 1.634 CTCF MA0139.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 17.205 0.645 244 1436 226 1454 264 0.003 252 0.003 3.267 1.615 E2F7 MA0758.1 Fork head / winged helix factors E2F-related factors vertebrates 24.200 0.458 14 1666 9 1671 14 0.000 9 0.000 6.187 1.601 Rxra MA0512.2 Nuclear receptors with C4 zinc fingers RXR-related receptors (NR2) vertebrates 22.648 0.503 74 1606 64 1616 76 0.001 67 0.001 4.087 1.528 MYBL1 MA0776.1 Tryptophan cluster factors Myb/SANT domain factors vertebrates 15.281 0.526 75 1605 65 1615 78 0.001 67 0.000 4.628 1.520 SOX21 MA0866.1 High-mobility group (HMG) domain factors SOX-related factors vertebrates 23.365 0.300 24 1656 18 1662 24 0.000 18 0.000 5.440 1.519 TP53 MA0106.3 p53 domain factors p53-related factors vertebrates 20.661 0.551 16 1664 11 1669 16 0.000 11 0.000 6.355 1.514 Creb5 MA0840.1 Basic leucine zipper factors (bZIP) CREB-related factors vertebrates 16.321 0.443 203 1477 188 1492 232 0.002 203 0.001 7.026 1.489 MYBL2 MA0777.1 Tryptophan cluster factors Myb/SANT domain factors vertebrates 16.774 0.467 12 1668 8 1672 12 0.000 8 0.000 5.427 1.382 TP63 MA0525.2 p53 domain factors p53-related factors vertebrates 24.335 0.468 6 1674 3 1677 6 0.000 3 0.000 7.277 1.372 KLF13 MA0657.1 C2H2 zinc finger factors Three-zinc finger Krüppel-related factors vertebrates 20.517 0.517 46 1634 39 1641 47 0.000 39 0.000 5.407 1.366 Nr2f6 MA0677.1 Nuclear receptors with C4 zinc fingers RXR-related receptors (NR2) vertebrates 18.175 0.483 66 1614 58 1622 66 0.001 64 0.000 0.908 1.343 TEAD3 MA0808.1 TEA domain factors TEF-1-related factors vertebrates 11.506 0.415 1445 235 1431 249 4010 0.017 4315 0.019 -13.325 1.341 ATF7 MA0834.1 Basic leucine zipper factors (bZIP) Jun-related factors vertebrates 17.313 0.456 139 1541 128 1552 161 0.001 134 0.001 8.703 1.340 Stat5a::Stat5b MA0519.1 STAT domain factors::STAT domain factors STAT factors::STAT factors vertebrates 13.332 0.399 1409 271 1396 284 3643 0.022 3605 0.021 2.047 1.243 Sox3 MA0514.1 High-mobility group (HMG) domain factors SOX-related factors vertebrates 13.042 0.401 1460 220 1449 231 4879 0.026 4585 0.025 13.821 1.183 SMAD3 MA0795.1 SMAD/NF-1 DNA-binding domain factors SMAD factors vertebrates 15.611 0.453 182 1498 172 1508 188 0.001 182 0.001 1.380 1.182 TBP MA0108.2 TATA-binding proteins TBP-related factors vertebrates 10.086 0.377 644 1036 629 1051 919 0.007 953 0.008 -4.329 1.173 POU4F2 MA0683.1 Homeo domain factors POU domain factors vertebrates 20.936 0.268 25 1655 21 1659 25 0.000 22 0.000 2.525 1.114 NEUROD2 MA0668.1 Basic helix-loop-helix factors (bHLH) Tal-related factors vertebrates 10.701 0.465 1364 316 1353 327 2925 0.016 3084 0.017 -9.196 1.107 Stat6 MA0520.1 STAT domain factors STAT factors vertebrates 14.063 0.406 606 1074 593 1087 867 0.007 815 0.007 7.032 1.100 E2F8 MA0865.1 Fork head / winged helix factors E2F-related factors vertebrates 20.970 0.542 52 1628 47 1633 52 0.000 48 0.000 1.970 1.074 OTX1 MA0711.1 Homeo domain factors Paired-related HD factors vertebrates 9.437 0.416 1377 303 1367 313 3923 0.017 4291 0.019 -16.107 1.067 Ahr::Arnt MA0006.1 Basic helix-loop-helix factors (bHLH)::Basic helix-loop-helix factors (bHLH) PAS domain factors::PAS domain factors vertebrates 9.532 0.715 1594 86 1588 92 6445 0.021 6420 0.021 0.698 1.049 SP4 MA0685.1 C2H2 zinc finger factors Three-zinc finger Krüppel-related factors vertebrates 19.967 0.677 564 1116 553 1127 858 0.008 881 0.008 -3.256 1.030 SOX4 MA0867.1 High-mobility group (HMG) domain factors SOX-related factors vertebrates 27.967 0.335 5 1675 3 1677 5 0.000 3 0.000 4.543 1.013 NFIC::TLX1 MA0119.1 SMAD/NF-1 DNA-binding domain factors::Homeo domain factors Nuclear factor 1::NK-related factors vertebrates 19.665 0.598 42 1638 38 1642 43 0.000 39 0.000 2.367 1.002 NKX2-8 MA0673.1 Homeo domain factors NK-related factors vertebrates 9.033 0.458 1676 4 1674 6 11858 0.058 12528 0.061 -18.656 0.976 NFIA MA0670.1 SMAD/NF-1 DNA-binding domain factors Nuclear factor 1 vertebrates 12.177 0.500 521 1159 512 1168 652 0.004 624 0.003 3.515 0.961 GATA5 MA0766.1 Other C4 zinc finger-type factors GATA-type zinc fingers vertebrates 8.347 0.307 1309 371 1301 379 3913 0.017 4479 0.019 -24.223 0.952 Pitx1 MA0682.1 Homeo domain factors Paired-related HD factors vertebrates 8.584 0.371 1320 360 1313 367 3329 0.014 3809 0.017 -22.244 0.914 Dmbx1 MA0883.1 Homeo domain factors Paired-related HD factors vertebrates 12.989 0.393 158 1522 153 1527 164 0.002 168 0.002 -1.302 0.902 T MA0009.2 T-Box factors Brachyury-related factors vertebrates 18.965 0.510 10 1670 8 1672 10 0.000 8 0.000 2.780 0.899 HSF4 MA0771.1 Heat shock factors HSF factors vertebrates 13.629 0.398 342 1338 336 1344 402 0.003 395 0.003 1.239 0.880 RARA(var.2) MA0730.1 Nuclear receptors with C4 zinc fingers Thyroid hormone receptor-related factors (NR1) vertebrates 22.768 0.535 13 1667 11 1669 13 0.000 11 0.000 2.445 0.870 SPIC MA0687.1 Tryptophan cluster factors Ets-related factors vertebrates 13.235 0.421 292 1388 287 1393 337 0.003 325 0.002 2.461 0.850 NFATC3 MA0625.1 Rel homology region (RHR) factors NFAT-related factors vertebrates 8.847 0.381 1270 410 1265 415 3014 0.016 2894 0.016 7.044 0.829 POU5F1B MA0792.1 Homeo domain factors POU domain factors vertebrates 10.558 0.254 718 962 713 967 1404 0.007 1520 0.007 -9.004 0.811 Stat4 MA0518.1 STAT domain factors STAT factors vertebrates 13.473 0.446 945 735 940 740 1505 0.011 1590 0.012 -8.080 0.810 OTX2 MA0712.1 Homeo domain factors Paired-related HD factors vertebrates 9.434 0.355 1352 328 1348 332 4296 0.019 5192 0.022 -35.644 0.803 Rhox11 MA0629.1 Homeo domain factors Paired-related HD factors vertebrates 12.000 0.431 153 1527 150 1530 167 0.002 162 0.001 1.592 0.794 GMEB2 MA0862.1 SAND domain factors GMEB vertebrates 9.886 0.392 453 1227 450 1230 549 0.002 561 0.002 -1.466 0.757 SPI1 MA0080.4 Tryptophan cluster factors Ets-related factors vertebrates 21.562 0.391 101 1579 99 1581 106 0.001 103 0.001 1.079 0.753 FOXD2 MA0847.1 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 8.622 0.249 1546 134 1544 136 8717 0.033 9682 0.037 -26.530 0.745 Alx4 MA0853.1 Homeo domain factors Paired-related HD factors vertebrates 13.490 0.348 45 1635 44 1636 46 0.000 46 0.000 -0.028 0.693 FOXO4 MA0848.1 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 10.660 0.295 1365 315 1364 316 4608 0.017 5015 0.019 -15.420 0.693 ZNF354C MA0130.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 8.958 0.615 1680 0 1679 1 15894 0.052 15988 0.052 -1.986 0.693 MZF1 MA0056.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 8.586 0.725 1679 1 1678 2 22481 0.073 19384 0.063 56.150 0.693 ETV5 MA0765.1 Tryptophan cluster factors Ets-related factors vertebrates 9.461 0.569 1436 244 1435 245 3410 0.018 3857 0.021 -23.072 0.693 PPARG MA0066.1 Nuclear receptors with C4 zinc fingers Thyroid hormone receptor-related factors (NR1) vertebrates 20.365 0.523 1 1679 0 1680 1 0.000 0 0.000 NA 0.693 Pou2f3 MA0627.1 Homeo domain factors POU domain factors vertebrates 15.067 0.318 94 1586 93 1587 98 0.001 104 0.001 -2.381 0.693 RHOXF1 MA0719.1 Homeo domain factors Paired-related HD factors vertebrates 8.182 0.438 1680 0 1679 1 21311 0.092 21474 0.093 -3.461 0.693 TFAP2C(var.2) MA0814.1 Basic helix-span-helix factors (bHSH) AP-2 vertebrates 11.387 0.715 1586 94 1585 95 8152 0.049 7807 0.047 13.150 0.693 ZNF410 MA0752.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 24.530 0.381 8 1672 7 1673 8 0.000 7 0.000 1.508 0.693 Sox1 MA0870.1 High-mobility group (HMG) domain factors SOX-related factors vertebrates 20.927 0.295 22 1658 21 1659 22 0.000 21 0.000 0.811 0.693 Tcf7 MA0769.1 Basic helix-loop-helix factors (bHLH) TCF-7-related factors vertebrates 16.918 0.356 142 1538 142 1538 157 0.001 155 0.001 0.530 0.645 SOX9 MA0077.1 High-mobility group (HMG) domain factors SOX-related factors vertebrates 9.079 0.358 775 905 776 904 1234 0.006 1237 0.006 -0.299 0.639 POU4F3 MA0791.1 Homeo domain factors POU domain factors vertebrates 13.812 0.287 69 1611 69 1611 72 0.001 72 0.001 -0.027 0.626 NFATC2 MA0152.1 Rel homology region (RHR) factors NFAT-related factors vertebrates 9.859 0.346 1359 321 1360 320 3740 0.014 3497 0.013 10.883 0.626 Gfi1 MA0038.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 9.470 0.391 1083 597 1085 595 2211 0.012 2176 0.012 2.330 0.611 DLX6 MA0882.1 Homeo domain factors NK-related factors vertebrates 8.327 0.229 1301 379 1303 377 4658 0.020 5350 0.023 -27.148 0.599 NRL MA0842.1 Basic leucine zipper factors (bZIP) Maf-related factors vertebrates 8.257 0.452 1323 357 1326 354 3165 0.019 3017 0.018 8.947 0.567 Dux MA0611.1 Homeo domain factors Paired-related HD factors vertebrates 11.804 0.338 586 1094 590 1090 854 0.004 849 0.004 0.450 0.559 PITX3 MA0714.1 Homeo domain factors Paired-related HD factors vertebrates 8.973 0.406 1230 450 1234 446 2786 0.014 3103 0.015 -17.263 0.549 POU2F2 MA0507.1 Homeo domain factors POU domain factors vertebrates 15.114 0.289 399 1281 403 1277 563 0.004 612 0.004 -7.193 0.544 JDP2 MA0655.1 Basic leucine zipper factors (bZIP) Fos-related factors vertebrates 15.102 0.355 328 1352 332 1348 374 0.002 381 0.002 -1.106 0.535 E2F3 MA0469.2 Fork head / winged helix factors E2F-related factors vertebrates 21.784 0.442 9 1671 9 1671 9 0.000 9 0.000 -0.044 0.523 Arx MA0874.1 Homeo domain factors Paired-related HD factors vertebrates 14.279 0.327 36 1644 37 1643 37 0.000 39 0.000 -1.349 0.522 DBP MA0639.1 Basic leucine zipper factors (bZIP) C/EBP-related vertebrates 13.741 0.344 420 1260 425 1255 551 0.004 590 0.004 -5.608 0.520 TGIF2 MA0797.1 Homeo domain factors TALE-type homeo domain factors vertebrates 18.378 0.488 77 1603 79 1601 77 0.001 84 0.001 -2.673 0.516 Bach1::Mafk MA0591.1 Basic leucine zipper factors (bZIP)::Basic leucine zipper factors (bZIP) Jun-related factors::Maf-related factors vertebrates 18.324 0.548 76 1604 78 1602 79 0.001 81 0.001 -0.888 0.515 HINFP MA0131.2 C2H2 zinc finger factors Factors with multiple dispersed zinc fingers vertebrates 13.024 0.717 1049 631 1055 625 2259 0.015 2280 0.015 -1.598 0.513 Nfe2l2 MA0150.2 Basic leucine zipper factors (bZIP) Jun-related factors vertebrates 15.876 0.496 73 1607 75 1605 74 0.001 79 0.001 -2.206 0.512 IRF2 MA0051.1 Tryptophan cluster factors Interferon-regulatory factors vertebrates 21.134 0.412 28 1652 29 1651 28 0.000 30 0.000 -1.579 0.502 RXRA::VDR MA0074.1 Nuclear receptors with C4 zinc fingers::Nuclear receptors with C4 zinc fingers RXR-related receptors (NR2)::Thyroid hormone receptor-related factors (NR1) vertebrates 20.451 0.527 24 1656 25 1655 24 0.000 28 0.000 -2.959 0.489 ZBTB7A MA0750.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 12.788 0.684 582 1098 589 1091 770 0.005 771 0.005 -0.165 0.488 NFATC1 MA0624.1 Rel homology region (RHR) factors NFAT-related factors vertebrates 8.040 0.411 1444 236 1449 231 4331 0.023 4185 0.023 7.141 0.482 STAT1 MA0137.3 STAT domain factors STAT factors vertebrates 14.582 0.415 1006 674 1015 665 1653 0.010 1657 0.010 -0.380 0.450 TFAP2B(var.2) MA0812.1 Basic helix-span-helix factors (bHSH) AP-2 vertebrates 12.568 0.731 1524 156 1529 151 6680 0.040 6351 0.038 13.857 0.446 ESR1 MA0112.3 Nuclear receptors with C4 zinc fingers Steroid hormone receptors (NR3) vertebrates 22.540 0.570 15 1665 16 1664 15 0.000 16 0.000 -1.067 0.445 ETV6 MA0645.1 Tryptophan cluster factors Ets-related factors vertebrates 12.354 0.564 1303 377 1311 369 2617 0.014 2988 0.016 -21.700 0.438 GRHL1 MA0647.1 Grainyhead domain factors Grainyhead-related factors vertebrates 14.286 0.390 134 1546 139 1541 141 0.001 153 0.001 -3.389 0.435 ZBED1 MA0749.1 C2H2 zinc finger factors BED zinc finger factors vertebrates 19.052 0.485 13 1667 14 1666 15 0.000 14 0.000 0.922 0.431 Alx1 MA0854.1 Homeo domain factors Paired-related HD factors vertebrates 13.599 0.333 53 1627 56 1624 53 0.000 58 0.001 -2.734 0.429 Hoxb5 MA0904.1 Homeo domain factors HOX-related factors vertebrates 12.676 0.334 52 1628 55 1625 55 0.000 62 0.001 -3.584 0.427 E2F2 MA0864.1 Fork head / winged helix factors E2F-related factors vertebrates 23.763 0.395 3 1677 3 1677 3 0.000 3 0.000 -0.075 0.421 Foxo1 MA0480.1 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 13.240 0.365 888 792 899 781 1548 0.009 1635 0.010 -7.222 0.414 EN2 MA0642.1 Homeo domain factors NK-related factors vertebrates 8.619 0.377 1325 355 1334 346 3483 0.019 3621 0.020 -7.395 0.409 GLIS3 MA0737.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 21.032 0.585 42 1638 45 1635 43 0.000 46 0.000 -1.684 0.404 TFCP2 MA0145.3 Grainyhead domain factors CP2-related factors vertebrates 11.701 0.441 421 1259 431 1249 507 0.003 525 0.003 -2.520 0.403 POU3F4 MA0789.1 Homeo domain factors POU domain factors vertebrates 13.378 0.229 517 1163 528 1152 862 0.004 900 0.004 -3.846 0.397 GLI2 MA0734.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 14.004 0.616 288 1392 297 1383 312 0.002 351 0.002 -7.249 0.392 Hes2 MA0616.1 Basic helix-loop-helix factors (bHLH) Hairy-related factors vertebrates 8.309 0.532 638 1042 650 1030 826 0.006 861 0.006 -4.356 0.389 Dlx2 MA0885.1 Homeo domain factors NK-related factors vertebrates 9.033 0.215 1325 355 1335 345 5068 0.022 5905 0.026 -31.286 0.386 ATF4 MA0833.1 Basic leucine zipper factors (bZIP) ATF-4-related factors vertebrates 15.609 0.443 149 1531 156 1524 157 0.001 172 0.001 -4.153 0.379 Id2 MA0617.1 Basic helix-loop-helix factors (bHLH) HLH domain only vertebrates 12.659 0.623 740 940 753 927 999 0.004 1112 0.005 -9.645 0.376 SNAI2 MA0745.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 9.486 0.570 1661 19 1663 17 8826 0.043 9258 0.045 -13.890 0.368 HSF1 MA0486.2 Heat shock factors HSF factors vertebrates 18.738 0.366 93 1587 99 1581 99 0.001 101 0.001 -0.745 0.359 MSX2 MA0708.1 Homeo domain factors NK-related factors vertebrates 9.959 0.264 993 687 1007 673 2097 0.009 2238 0.010 -8.522 0.355 BARX1 MA0875.1 Homeo domain factors NK-related factors vertebrates 8.892 0.306 1362 318 1373 307 4886 0.021 6103 0.026 -44.731 0.353 NFAT5 MA0606.1 Rel homology region (RHR) factors NFAT-related factors vertebrates 10.151 0.333 1391 289 1402 278 4681 0.025 4480 0.024 9.532 0.343 ARNT::HIF1A MA0259.1 Basic helix-loop-helix factors (bHLH)::Basic helix-loop-helix factors (bHLH) PAS domain factors::PAS domain factors vertebrates 9.740 0.657 1493 187 1502 178 4849 0.021 5343 0.023 -19.415 0.342 Hoxa9 MA0594.1 Homeo domain factors HOX-related factors vertebrates 13.740 0.326 323 1357 335 1345 407 0.002 434 0.003 -4.335 0.337 SPIB MA0081.1 Tryptophan cluster factors Ets-related factors vertebrates 9.060 0.466 1639 41 1643 37 8395 0.032 7876 0.030 15.618 0.333 PKNOX1 MA0782.1 Homeo domain factors TALE-type homeo domain factors vertebrates 21.435 0.506 68 1612 74 1606 68 0.000 79 0.001 -4.315 0.321 MAFG MA0659.1 Basic leucine zipper factors (bZIP) Maf-related factors vertebrates 16.353 0.463 5 1675 6 1674 5 0.000 6 0.000 -1.919 0.320 Hoxc9 MA0485.1 Homeo domain factors HOX-related factors vertebrates 13.615 0.344 244 1436 256 1424 294 0.002 311 0.002 -3.510 0.307 CUX2 MA0755.1 Homeo domain factors HD-CUT factors vertebrates 11.691 0.277 290 1390 303 1377 362 0.002 390 0.002 -4.518 0.305 BATF3 MA0835.1 Basic leucine zipper factors (bZIP) B-ATF-related factors vertebrates 23.217 0.484 10 1670 12 1668 10 0.000 12 0.000 -2.203 0.303 MAFK MA0496.1 Basic leucine zipper factors (bZIP) Maf-related factors vertebrates 13.869 0.395 613 1067 630 1050 892 0.007 902 0.007 -1.340 0.301 RARA::RXRA MA0159.1 Nuclear receptors with C4 zinc fingers::Nuclear receptors with C4 zinc fingers Thyroid hormone receptor-related factors (NR1)::RXR-related receptors (NR2) vertebrates 16.004 0.535 73 1607 80 1600 74 0.001 82 0.001 -3.670 0.293 LEF1 MA0768.1 High-mobility group (HMG) domain factors TCF-7-related factors vertebrates 17.861 0.425 72 1608 79 1601 78 0.001 82 0.001 -1.738 0.291 NKX6-1 MA0674.1 Homeo domain factors NK-related factors vertebrates 9.183 0.199 1158 522 1175 505 3502 0.015 3845 0.017 -15.841 0.288 SREBF1 MA0595.1 Basic helix-loop-helix factors (bHLH) bHLH-ZIP factors vertebrates 13.517 0.569 1036 644 1054 626 1664 0.009 1867 0.010 -14.983 0.287 STAT3 MA0144.2 STAT domain factors STAT factors vertebrates 13.049 0.436 1465 215 1477 203 4456 0.027 4521 0.027 -3.333 0.286 Mafb MA0117.2 Basic leucine zipper factors (bZIP) Maf-related factors vertebrates 11.336 0.444 598 1082 616 1064 819 0.005 815 0.005 0.446 0.284 HMBOX1 MA0895.1 Homeo domain factors POU domain factors vertebrates 9.583 0.347 798 882 817 863 1363 0.007 1417 0.008 -4.600 0.281 FOXP3 MA0850.1 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 8.594 0.299 1525 155 1536 144 7417 0.028 7832 0.030 -12.681 0.266 BCL6B MA0731.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 29.809 0.401 3 1677 4 1676 3 0.000 4 0.000 -2.125 0.257 PAX4 MA0068.2 Paired box factors Paired plus homeo domain vertebrates 9.469 0.309 593 1087 613 1067 935 0.004 983 0.004 -4.376 0.255 ONECUT1 MA0679.1 Homeo domain factors HD-CUT factors vertebrates 16.237 0.243 128 1552 139 1541 140 0.001 176 0.001 -10.186 0.251 POU2F1 MA0785.1 Homeo domain factors POU domain factors vertebrates 12.044 0.265 428 1252 447 1233 635 0.004 735 0.005 -12.845 0.243 TBX4 MA0806.1 T-Box factors TBX2-related factors vertebrates 9.891 0.500 1549 131 1560 120 4578 0.020 5266 0.023 -27.200 0.243 OLIG3 MA0827.1 Basic helix-loop-helix factors (bHLH) Tal-related factors vertebrates 11.442 0.387 708 972 730 950 1050 0.006 1152 0.006 -9.575 0.237 TP73 MA0861.1 p53 domain factors p53-related factors vertebrates 17.517 0.483 61 1619 69 1611 62 0.001 70 0.001 -4.084 0.236 CUX1 MA0754.1 Homeo domain factors HD-CUT factors vertebrates 11.472 0.304 355 1325 374 1306 456 0.002 517 0.003 -8.527 0.225 LHX6 MA0658.1 Homeo domain factors HD-LIM factors vertebrates 10.963 0.288 665 1015 688 992 1101 0.006 1101 0.006 -0.043 0.222 BHLHE22 MA0818.1 Basic helix-loop-helix factors (bHLH) Tal-related factors vertebrates 13.037 0.384 344 1336 363 1317 412 0.002 455 0.002 -6.413 0.221 DUXA MA0884.1 Homeo domain factors Paired-related HD factors vertebrates 12.572 0.301 289 1391 307 1373 352 0.002 401 0.003 -8.866 0.217 FOXA1 MA0148.3 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 13.765 0.334 844 836 868 812 1647 0.013 1796 0.015 -13.778 0.216 CENPB MA0637.1 Psq-type HTH domain - vertebrates 13.999 0.562 410 1270 431 1249 470 0.004 510 0.004 -6.910 0.211 REL MA0101.1 Rel homology region (RHR) factors NF-kappaB-related factors vertebrates 10.515 0.559 1121 559 1144 536 1899 0.010 1983 0.011 -6.051 0.209 Hmx1 MA0896.1 Homeo domain factors NK-related factors vertebrates 13.599 0.383 49 1631 57 1623 51 0.000 63 0.001 -6.261 0.207 E2F1 MA0024.3 Fork head / winged helix factors E2F-related factors vertebrates 13.048 0.553 196 1484 212 1468 209 0.001 235 0.002 -5.907 0.204 Crem MA0609.1 Basic leucine zipper factors (bZIP) CREB-related factors vertebrates 12.449 0.416 281 1399 300 1380 326 0.002 340 0.002 -2.432 0.199 FOXI1 MA0042.2 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 11.617 0.289 1117 563 1141 539 2532 0.010 2721 0.010 -9.688 0.197 Hoxd3 MA0912.1 Homeo domain factors HOX-related factors vertebrates 11.598 0.341 157 1523 172 1508 174 0.002 205 0.002 -8.696 0.194 FOXD1 MA0031.1 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 11.926 0.275 848 832 874 806 1570 0.007 1677 0.007 -7.462 0.193 TGIF1 MA0796.1 Homeo domain factors TALE-type homeo domain factors vertebrates 22.281 0.543 23 1657 29 1651 23 0.000 32 0.000 -5.544 0.179 Nkx2-5(var.2) MA0503.1 Homeo domain factors NK-related factors vertebrates 12.615 0.534 1401 279 1421 259 3164 0.019 3287 0.020 -7.257 0.176 CREB3 MA0638.1 Basic leucine zipper factors (bZIP) CREB-related factors vertebrates 15.483 0.552 96 1584 109 1571 97 0.001 114 0.001 -5.986 0.170 MTF1 MA0863.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 20.407 0.620 15 1665 20 1660 15 0.000 20 0.000 -4.219 0.167 OLIG2 MA0678.1 Basic helix-loop-helix factors (bHLH) Tal-related factors vertebrates 12.953 0.374 368 1312 392 1288 457 0.002 541 0.003 -11.468 0.164 HEY1 MA0823.1 Basic helix-loop-helix factors (bHLH) Hairy-related factors vertebrates 12.269 0.677 834 846 863 817 1345 0.007 1438 0.008 -7.832 0.163 POU1F1 MA0784.1 Homeo domain factors POU domain factors vertebrates 14.958 0.281 104 1576 118 1562 114 0.001 140 0.001 -8.252 0.161 Spz1 MA0111.1 Basic helix-loop-helix factors (bHLH) - vertebrates 11.907 0.538 664 1016 693 987 859 0.005 921 0.005 -6.835 0.158 PAX9 MA0781.1 Paired box factors Paired domain only vertebrates 22.261 0.612 19 1661 25 1655 19 0.000 42 0.000 -14.661 0.155 Pax6 MA0069.1 Paired box factors Paired plus homeo domain vertebrates 13.798 0.432 41 1639 50 1630 41 0.000 54 0.000 -6.648 0.155 BSX MA0876.1 Homeo domain factors NK-related factors vertebrates 8.513 0.311 1369 311 1392 288 5070 0.022 5814 0.025 -28.028 0.150 NFE2 MA0841.1 Basic leucine zipper factors (bZIP) Jun-related factors vertebrates 16.895 0.417 218 1462 239 1441 231 0.001 262 0.002 -6.384 0.144 FOXO3 MA0157.2 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 13.427 0.265 773 907 805 875 1353 0.006 1488 0.006 -9.973 0.136 Gmeb1 MA0615.1 SAND domain factors GMEB vertebrates 8.363 0.521 459 1221 488 1192 553 0.005 626 0.006 -12.105 0.134 Vdr MA0693.1 Nuclear receptors with C4 zinc fingers Thyroid hormone receptor-related factors (NR1) vertebrates 21.487 0.479 60 1620 72 1608 62 0.001 77 0.001 -6.866 0.133 Hnf4a MA0114.3 Nuclear receptors with C4 zinc fingers RXR-related receptors (NR2) vertebrates 21.667 0.508 33 1647 42 1638 33 0.000 45 0.000 -7.184 0.129 Esrra MA0592.2 Nuclear receptors with C4 zinc fingers Steroid hormone receptors (NR3) vertebrates 17.764 0.409 212 1468 234 1446 235 0.001 267 0.002 -6.528 0.129 TFAP2A MA0003.3 Basic helix-span-helix factors (bHSH) AP-2 vertebrates 11.101 0.742 1614 66 1626 54 13951 0.083 12967 0.077 29.687 0.120 NFKB2 MA0778.1 Rel homology region (RHR) factors NF-kappaB-related factors vertebrates 16.488 0.698 427 1253 458 1222 495 0.003 612 0.004 -17.124 0.111 JUN(var.2) MA0489.1 Basic leucine zipper factors (bZIP) Jun-related factors vertebrates 13.941 0.426 502 1178 535 1145 653 0.005 714 0.005 -8.604 0.108 HLF MA0043.2 Basic leucine zipper factors (bZIP) C/EBP-related vertebrates 11.834 0.365 609 1071 644 1036 863 0.006 969 0.006 -11.875 0.105 IRF7 MA0772.1 Tryptophan cluster factors Interferon-regulatory factors vertebrates 17.627 0.419 120 1560 139 1541 131 0.001 147 0.001 -4.967 0.103 FOXG1 MA0613.1 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 13.341 0.225 977 703 1013 667 2215 0.010 2656 0.012 -24.395 0.102 HOXC13 MA0907.1 Homeo domain factors HOX-related factors vertebrates 14.190 0.361 240 1440 266 1414 272 0.002 301 0.002 -5.577 0.101 Sox17 MA0078.1 High-mobility group (HMG) domain factors SOX-related factors vertebrates 10.502 0.384 1090 590 1125 555 2098 0.010 2354 0.011 -15.974 0.100 HEY2 MA0649.1 Basic helix-loop-helix factors (bHLH) Hairy-related factors vertebrates 11.968 0.672 891 789 928 752 1369 0.007 1485 0.008 -9.604 0.099 Arnt MA0004.1 Basic helix-loop-helix factors (bHLH) PAS domain factors vertebrates 10.992 0.642 943 737 980 700 1616 0.005 1778 0.006 -9.479 0.097 RUNX1 MA0002.2 Runt domain factors Runt-related factors vertebrates 10.401 0.502 1260 420 1292 388 2701 0.016 2761 0.016 -3.884 0.096 FOXO6 MA0849.1 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 11.992 0.294 1275 405 1307 373 3713 0.014 4182 0.016 -19.404 0.093 TCF7L2 MA0523.1 Basic helix-loop-helix factors (bHLH) TCF-7-related factors vertebrates 13.486 0.398 743 937 781 899 1131 0.009 1172 0.009 -4.551 0.092 ESR2 MA0258.2 Nuclear receptors with C4 zinc fingers Steroid hormone receptors (NR3) vertebrates 13.119 0.581 695 985 733 947 970 0.008 969 0.008 0.077 0.091 TBX1 MA0805.1 T-Box factors TBX1-related factors vertebrates 12.823 0.498 1090 590 1127 553 1917 0.008 2191 0.009 -16.685 0.087 Rarb MA0857.1 Nuclear receptors with C4 zinc fingers Thyroid hormone receptor-related factors (NR1) vertebrates 26.391 0.422 7 1673 12 1668 7 0.000 12 0.000 -5.814 0.087 OLIG1 MA0826.1 Basic helix-loop-helix factors (bHLH) Tal-related factors vertebrates 14.663 0.334 308 1372 339 1341 367 0.002 436 0.002 -10.492 0.084 XBP1 MA0844.1 Basic leucine zipper factors (bZIP) XBP-1-related factors vertebrates 15.475 0.537 122 1558 143 1537 127 0.001 152 0.001 -7.618 0.083 FOXL1 MA0033.2 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 10.626 0.221 1422 258 1450 230 6156 0.023 6911 0.026 -24.428 0.081 MAF::NFE2 MA0501.1 Basic leucine zipper factors (bZIP)::Basic leucine zipper factors (bZIP) Maf-related factors::Jun-related factors vertebrates 17.621 0.429 50 1630 64 1616 51 0.000 67 0.001 -7.598 0.079 MAX::MYC MA0059.1 Basic helix-loop-helix factors (bHLH)::Basic helix-loop-helix factors (bHLH) bHLH-ZIP factors::bHLH-ZIP factors vertebrates 14.237 0.602 286 1394 317 1363 306 0.002 359 0.002 -9.316 0.078 CDX1 MA0878.1 Homeo domain factors HOX-related factors vertebrates 9.270 0.234 1058 622 1097 583 3017 0.015 3600 0.018 -29.472 0.078 Myc MA0147.2 Basic helix-loop-helix factors (bHLH) bHLH-ZIP factors vertebrates 13.032 0.584 1176 504 1213 467 2142 0.012 2487 0.013 -22.082 0.077 Nobox MA0125.1 Homeo domain factors Paired-related HD factors vertebrates 9.573 0.260 828 852 869 811 1603 0.007 1811 0.008 -13.924 0.076 ELF5 MA0136.2 Tryptophan cluster factors Ets-related factors vertebrates 10.425 0.538 1440 240 1468 212 3536 0.021 3723 0.022 -10.354 0.074 JUN MA0488.1 Basic leucine zipper factors (bZIP) Jun-related factors vertebrates 15.128 0.380 591 1089 631 1049 773 0.005 882 0.006 -13.315 0.073 POU3F1 MA0786.1 Homeo domain factors POU domain factors vertebrates 11.957 0.245 373 1307 408 1272 541 0.004 671 0.004 -17.458 0.073 TEF MA0843.1 TEA domain factors TEF-1-related factors vertebrates 14.579 0.317 249 1431 280 1400 298 0.002 366 0.002 -12.357 0.067 TBX19 MA0804.1 T-Box factors Brachyury-related factors vertebrates 17.480 0.448 1 1679 3 1677 1 0.000 3 0.000 -5.230 0.064 BARHL2 MA0635.1 Homeo domain factors NK-related factors vertebrates 8.495 0.352 1416 264 1447 233 6397 0.035 6975 0.038 -22.406 0.062 POU3F2 MA0787.1 Homeo domain factors POU domain factors vertebrates 13.773 0.240 272 1408 305 1375 354 0.002 410 0.003 -9.624 0.062 POU4F1 MA0790.1 Homeo domain factors POU domain factors vertebrates 13.126 0.257 129 1551 153 1527 147 0.001 176 0.001 -8.211 0.062 Hoxd8 MA0910.1 Homeo domain factors HOX-related factors vertebrates 12.824 0.247 35 1645 48 1632 36 0.000 49 0.000 -7.685 0.061 Nkx2-5 MA0063.1 Homeo domain factors NK-related factors vertebrates 8.270 0.218 1247 433 1285 395 4405 0.017 5160 0.020 -28.151 0.061 ONECUT2 MA0756.1 Homeo domain factors HD-CUT factors vertebrates 15.765 0.228 113 1567 136 1544 124 0.001 177 0.001 -14.941 0.059 BHLHE41 MA0636.1 Basic helix-loop-helix factors (bHLH) Hairy-related factors vertebrates 15.486 0.585 345 1335 382 1298 397 0.002 458 0.002 -9.055 0.057 Arid3a MA0151.1 ARID domain factors ARID-related factors vertebrates 9.896 0.062 1085 595 1128 552 3421 0.011 4078 0.013 -25.425 0.056 Lhx8 MA0705.1 Homeo domain factors HD-LIM factors vertebrates 8.840 0.303 1248 432 1287 393 3032 0.013 3187 0.014 -7.880 0.056 Rarb(var.2) MA0858.1 Nuclear receptors with C4 zinc fingers Thyroid hormone receptor-related factors (NR1) vertebrates 24.795 0.471 9 1671 16 1664 9 0.000 16 0.000 -7.251 0.055 Lhx4 MA0704.1 Homeo domain factors HD-LIM factors vertebrates 8.328 0.194 1157 523 1199 481 3620 0.016 4408 0.019 -33.960 0.054 HOXA10 MA0899.1 Homeo domain factors HOX-related factors vertebrates 9.141 0.292 824 856 870 810 1804 0.011 2126 0.013 -23.364 0.054 MAX MA0058.3 Basic helix-loop-helix factors (bHLH) bHLH-ZIP factors vertebrates 11.435 0.606 1066 614 1110 570 1799 0.010 2019 0.011 -15.621 0.053 MSX1 MA0666.1 Homeo domain factors NK-related factors vertebrates 8.661 0.279 1234 446 1274 406 3533 0.015 4018 0.017 -21.896 0.053 PROX1 MA0794.1 Homeo domain factors HD-PROS factors vertebrates 16.936 0.455 134 1546 160 1520 139 0.001 183 0.001 -11.299 0.051 NEUROG2 MA0669.1 Basic helix-loop-helix factors (bHLH) Tal-related factors vertebrates 14.502 0.395 335 1345 373 1307 401 0.002 465 0.003 -9.427 0.051 MAFF MA0495.1 Basic leucine zipper factors (bZIP) Maf-related factors vertebrates 13.864 0.411 198 1482 229 1451 220 0.002 254 0.002 -9.092 0.050 FOXC1 MA0032.2 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 11.875 0.201 879 801 926 754 2251 0.013 2782 0.017 -33.730 0.050 Twist2 MA0633.1 Basic helix-loop-helix factors (bHLH) Tal-related factors vertebrates 11.928 0.423 552 1128 597 1083 735 0.004 884 0.005 -15.922 0.048 PRRX1 MA0716.1 Homeo domain factors Paired-related HD factors vertebrates 8.226 0.213 1145 535 1189 491 3352 0.015 4011 0.017 -29.753 0.047 Nr2e1 MA0676.1 Nuclear receptors with C4 zinc fingers RXR-related receptors (NR2) vertebrates 11.374 0.291 851 829 899 781 1499 0.007 1635 0.008 -10.177 0.046 FOXF2 MA0030.1 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 14.824 0.334 130 1550 157 1523 139 0.001 177 0.001 -10.720 0.043 Msx3 MA0709.1 Homeo domain factors NK-related factors vertebrates 9.864 0.246 1107 573 1154 526 2877 0.012 3365 0.015 -24.028 0.040 CDX2 MA0465.1 Homeo domain factors HOX-related factors vertebrates 13.813 0.281 742 938 792 888 1324 0.008 1535 0.009 -17.992 0.039 JUND(var.2) MA0492.1 Basic leucine zipper factors (bZIP) Jun-related factors vertebrates 15.021 0.393 556 1124 604 1076 732 0.006 818 0.007 -11.727 0.038 LBX1 MA0618.1 Homeo domain factors NK-related factors vertebrates 10.149 0.240 955 725 1005 675 2168 0.009 2391 0.010 -13.018 0.038 Hmx2 MA0897.1 Homeo domain factors NK-related factors vertebrates 14.390 0.335 21 1659 33 1647 21 0.000 33 0.000 -8.642 0.037 GBX1 MA0889.1 Homeo domain factors HOX-related factors vertebrates 10.843 0.319 817 863 868 812 1478 0.008 1582 0.009 -8.352 0.037 PAX3 MA0780.1 Paired box factors Paired plus homeo domain vertebrates 15.425 0.145 174 1506 206 1474 208 0.001 245 0.001 -7.507 0.037 NR4A2 MA0160.1 Nuclear receptors with C4 zinc fingers NGFI-B-related receptors (NR4) vertebrates 10.165 0.491 1302 378 1344 336 2840 0.012 3181 0.014 -17.278 0.035 IRF9 MA0653.1 Tryptophan cluster factors Interferon-regulatory factors vertebrates 24.834 0.425 11 1669 20 1660 13 0.000 21 0.000 -6.795 0.035 SPDEF MA0686.1 Tryptophan cluster factors Ets-related factors vertebrates 14.474 0.536 533 1147 582 1098 651 0.004 795 0.005 -17.015 0.034 FOXP2 MA0593.1 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 13.802 0.305 756 924 808 872 1386 0.008 1550 0.009 -13.929 0.034 HSF2 MA0770.1 Heat shock factors HSF factors vertebrates 17.218 0.359 138 1542 168 1512 153 0.001 173 0.001 -5.512 0.032 NR1H2::RXRA MA0115.1 Nuclear receptors with C4 zinc fingers::Nuclear receptors with C4 zinc fingers Thyroid hormone receptor-related factors (NR1)::RXR-related receptors (NR2) vertebrates 27.878 0.445 1 1679 4 1676 1 0.000 4 0.000 -6.247 0.032 PKNOX2 MA0783.1 Homeo domain factors TALE-type homeo domain factors vertebrates 21.223 0.512 39 1641 56 1624 39 0.000 60 0.000 -9.420 0.031 SRY MA0084.1 High-mobility group (HMG) domain factors SOX-related factors vertebrates 9.193 0.238 962 718 1016 664 2251 0.011 2698 0.013 -26.044 0.027 Foxa2 MA0047.2 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 13.268 0.315 595 1085 648 1032 949 0.006 1080 0.007 -13.900 0.027 PAX1 MA0779.1 Paired box factors Paired domain only vertebrates 19.655 0.599 51 1629 71 1609 51 0.000 89 0.001 -16.639 0.027 STAT1::STAT2 MA0517.1 STAT domain factors::STAT domain factors STAT factors::STAT factors vertebrates 16.390 0.373 250 1430 291 1389 298 0.002 329 0.003 -6.659 0.025 NOTO MA0710.1 Homeo domain factors NK-related factors vertebrates 9.584 0.280 1277 403 1325 355 4101 0.022 4831 0.026 -33.732 0.022 EN1 MA0027.2 Homeo domain factors NK-related factors vertebrates 9.349 0.249 1206 474 1257 423 3700 0.016 4342 0.019 -27.886 0.021 Rarg(var.2) MA0860.1 Nuclear receptors with C4 zinc fingers Thyroid hormone receptor-related factors (NR1) vertebrates 25.520 0.537 8 1672 17 1663 8 0.000 17 0.000 -9.035 0.021 HOXD12 MA0873.1 Homeo domain factors HOX-related factors vertebrates 14.187 0.355 274 1406 318 1362 313 0.002 379 0.002 -11.286 0.021 mix-a MA0621.1 Homeo domain factors Paired-related HD factors vertebrates 12.512 0.199 287 1393 332 1348 364 0.002 451 0.003 -13.635 0.021 GLIS1 MA0735.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 25.361 0.673 12 1668 23 1657 12 0.000 23 0.000 -9.207 0.020 BHLHE23 MA0817.1 Basic helix-loop-helix factors (bHLH) Tal-related factors vertebrates 14.991 0.338 186 1494 224 1456 214 0.001 268 0.002 -11.464 0.020 RARA MA0729.1 Nuclear receptors with C4 zinc fingers Thyroid hormone receptor-related factors (NR1) vertebrates 28.136 0.482 2 1678 7 1673 2 0.000 7 0.000 -8.065 0.020 Mlxip MA0622.1 Basic helix-loop-helix factors (bHLH) bHLH-ZIP factors vertebrates 12.531 0.625 740 940 799 881 1081 0.005 1208 0.005 -10.401 0.019 NFIL3 MA0025.1 Basic leucine zipper factors (bZIP) C/EBP-related vertebrates 14.139 0.265 243 1437 286 1394 286 0.002 384 0.002 -16.634 0.019 ETS1 MA0098.3 Tryptophan cluster factors Ets-related factors vertebrates 12.150 0.528 1100 580 1156 524 1780 0.010 2121 0.011 -23.602 0.018 Sox5 MA0087.1 High-mobility group (HMG) domain factors SOX-related factors vertebrates 10.831 0.199 795 885 856 824 1596 0.006 1915 0.007 -19.400 0.016 BATF::JUN MA0462.1 Basic leucine zipper factors (bZIP)::Basic leucine zipper factors (bZIP) B-ATF-related factors::Jun-related factors vertebrates 13.645 0.367 762 918 823 857 1251 0.007 1344 0.008 -8.494 0.016 IRF8 MA0652.1 Tryptophan cluster factors Interferon-regulatory factors vertebrates 22.505 0.465 24 1656 40 1640 27 0.000 42 0.000 -8.689 0.016 Foxj2 MA0614.1 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 11.782 0.247 1096 584 1154 526 2975 0.013 3507 0.015 -25.664 0.015 IRF1 MA0050.2 Tryptophan cluster factors Interferon-regulatory factors vertebrates 17.950 0.357 124 1556 158 1522 139 0.002 178 0.002 -13.437 0.015 USF2 MA0526.1 Basic helix-loop-helix factors (bHLH) bHLH-ZIP factors vertebrates 13.559 0.555 1042 638 1102 578 1689 0.010 1940 0.012 -19.063 0.014 Creb3l2 MA0608.1 Basic leucine zipper factors (bZIP) CREB-related factors vertebrates 12.997 0.624 949 731 1011 669 1422 0.007 1684 0.008 -19.278 0.014 ZNF143 MA0088.2 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 22.060 0.491 50 1630 73 1607 51 0.000 74 0.001 -10.723 0.014 PBX1 MA0070.1 Homeo domain factors TALE-type homeo domain factors vertebrates 14.641 0.310 110 1570 143 1537 120 0.001 155 0.001 -9.769 0.013 PAX7 MA0680.1 Paired box factors Paired plus homeo domain vertebrates 16.430 0.154 124 1556 159 1521 143 0.001 183 0.001 -9.381 0.013 POU3F3 MA0788.1 Homeo domain factors POU domain factors vertebrates 13.499 0.222 224 1456 269 1411 282 0.002 371 0.003 -16.711 0.012 RUNX3 MA0684.1 Runt domain factors Runt-related factors vertebrates 11.687 0.452 884 796 948 732 1317 0.007 1432 0.008 -9.693 0.012 Shox2 MA0720.1 Homeo domain factors Paired-related HD factors vertebrates 9.249 0.214 1200 480 1257 423 3813 0.017 4628 0.020 -34.296 0.012 MNX1 MA0707.1 Homeo domain factors HOX-related factors vertebrates 8.729 0.228 1011 669 1076 604 2744 0.015 3569 0.019 -44.161 0.009 Hic1 MA0739.1 C2H2 zinc finger factors Factors with multiple dispersed zinc fingers vertebrates 9.519 0.606 1610 70 1634 46 6362 0.031 6376 0.031 -0.624 0.009 Nr1h3::Rxra MA0494.1 Nuclear receptors with C4 zinc fingers::Nuclear receptors with C4 zinc fingers Thyroid hormone receptor-related factors (NR1)::RXR-related receptors (NR2) vertebrates 13.598 0.497 238 1442 287 1393 253 0.003 330 0.003 -18.539 0.009 Atf3 MA0605.1 Basic leucine zipper factors (bZIP) Fos-related factors vertebrates 11.483 0.498 952 728 1019 661 1494 0.006 1729 0.007 -16.089 0.009 Hoxd9 MA0913.1 Homeo domain factors HOX-related factors vertebrates 9.118 0.300 939 741 1007 673 2415 0.013 2997 0.016 -33.954 0.008 HOXA5 MA0158.1 Homeo domain factors HOX-related factors vertebrates 8.759 0.315 1451 229 1496 184 5364 0.023 6664 0.029 -45.785 0.008 Arid3b MA0601.1 ARID domain factors ARID-related factors vertebrates 10.307 0.153 638 1042 706 974 1329 0.008 1683 0.010 -28.812 0.008 RUNX2 MA0511.2 Runt domain factors Runt-related factors vertebrates 11.551 0.475 1101 579 1166 514 1839 0.009 2039 0.010 -13.404 0.008 HES5 MA0821.1 Basic helix-loop-helix factors (bHLH) Hairy-related factors vertebrates 18.532 0.704 137 1543 177 1503 141 0.001 209 0.001 -16.330 0.008 MGA MA0801.1 T-Box factors TBX6-related factors vertebrates 10.832 0.509 1503 177 1543 137 4264 0.018 4642 0.020 -15.922 0.008 FOSL1 MA0477.1 Basic leucine zipper factors (bZIP) Fos-related factors vertebrates 14.281 0.477 821 859 891 789 1173 0.007 1409 0.008 -20.986 0.007 BHLHE40 MA0464.2 Basic helix-loop-helix factors (bHLH) Hairy-related factors vertebrates 12.695 0.599 832 848 902 778 1271 0.007 1378 0.007 -9.194 0.007 GSC MA0648.1 Homeo domain factors Paired-related HD factors vertebrates 9.643 0.433 966 714 1036 644 1750 0.009 2483 0.013 -46.885 0.006 ESRRB MA0141.3 Nuclear receptors with C4 zinc fingers Steroid hormone receptors (NR3) vertebrates 16.338 0.420 277 1403 332 1348 317 0.002 385 0.002 -11.536 0.006 Lhx3 MA0135.1 Homeo domain factors HD-LIM factors vertebrates 16.354 0.131 157 1523 201 1479 180 0.001 240 0.002 -14.003 0.006 Foxk1 MA0852.1 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 15.268 0.300 84 1596 118 1562 89 0.001 125 0.001 -13.309 0.005 Gabpa MA0062.2 Tryptophan cluster factors Ets-related factors vertebrates 13.335 0.647 978 702 1050 630 1528 0.009 1944 0.012 -31.526 0.005 TBX20 MA0689.1 T-Box factors TBX1-related factors vertebrates 13.845 0.429 351 1329 413 1267 410 0.002 481 0.003 -10.784 0.005 TBR1 MA0802.1 T-Box factors TBrain-related factors vertebrates 12.472 0.439 648 1032 722 958 890 0.005 1024 0.006 -13.318 0.004 TBX2 MA0688.1 T-Box factors TBX2-related factors vertebrates 10.262 0.450 747 933 823 857 1066 0.006 1271 0.008 -19.187 0.004 Klf12 MA0742.1 C2H2 zinc finger factors Three-zinc finger Krüppel-related factors vertebrates 16.798 0.612 557 1123 630 1050 772 0.006 959 0.008 -23.522 0.004 Hmx3 MA0898.1 Homeo domain factors NK-related factors vertebrates 13.950 0.330 17 1663 35 1645 17 0.000 35 0.000 -12.574 0.004 Foxq1 MA0040.1 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 14.070 0.202 303 1377 364 1316 393 0.002 520 0.003 -18.531 0.004 POU6F1 MA0628.1 Homeo domain factors POU domain factors vertebrates 10.097 0.209 319 1361 383 1297 419 0.002 531 0.003 -15.422 0.003 FOXC2 MA0846.1 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 11.607 0.229 782 898 861 819 1706 0.011 2158 0.014 -34.000 0.003 HNF1A MA0046.2 Homeo domain factors POU domain factors vertebrates 15.880 0.226 161 1519 211 1469 177 0.001 251 0.002 -18.136 0.002 LHX2 MA0700.1 Homeo domain factors HD-LIM factors vertebrates 10.311 0.309 977 703 1057 623 2010 0.011 2435 0.013 -27.472 0.002 ERG MA0474.2 Tryptophan cluster factors Ets-related factors vertebrates 11.781 0.514 1182 498 1255 425 2090 0.011 2528 0.014 -27.794 0.002 ONECUT3 MA0757.1 Homeo domain factors HD-CUT factors vertebrates 17.036 0.190 117 1563 162 1518 126 0.001 211 0.002 -21.937 0.002 Npas2 MA0626.1 Basic helix-loop-helix factors (bHLH) PAS domain factors vertebrates 11.517 0.589 1008 672 1088 592 1690 0.009 1945 0.011 -18.432 0.002 HNF1B MA0153.2 Homeo domain factors POU domain factors vertebrates 16.242 0.207 88 1592 128 1552 98 0.001 140 0.001 -12.830 0.002 DMRT3 MA0610.1 DM-type intertwined zinc finger factors DMRT vertebrates 11.236 0.344 392 1288 464 1216 492 0.003 656 0.004 -21.311 0.002 ETV4 MA0764.1 Tryptophan cluster factors Ets-related factors vertebrates 10.625 0.519 1085 595 1163 517 1770 0.010 2223 0.012 -30.619 0.002 ZBTB18 MA0698.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 15.425 0.459 515 1165 593 1087 673 0.005 785 0.006 -14.492 0.002 FOXB1 MA0845.1 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 12.241 0.200 531 1149 611 1069 929 0.006 1227 0.007 -28.361 0.002 TBX15 MA0803.1 T-Box factors TBX1-related factors vertebrates 13.306 0.505 982 698 1065 615 1642 0.007 1935 0.008 -18.965 0.001 VSX1 MA0725.1 Homeo domain factors Paired-related HD factors vertebrates 8.078 0.217 873 807 958 722 2100 0.009 2565 0.011 -26.165 0.001 Atf1 MA0604.1 Basic leucine zipper factors (bZIP) CREB-related factors vertebrates 10.519 0.476 825 855 911 769 1212 0.005 1429 0.006 -16.327 0.001 HES7 MA0822.1 Basic helix-loop-helix factors (bHLH) Hairy-related factors vertebrates 19.784 0.730 77 1603 117 1563 80 0.001 132 0.001 -15.709 0.001 FOS MA0476.1 Basic leucine zipper factors (bZIP) Fos-related factors vertebrates 13.637 0.423 629 1051 715 965 870 0.005 1062 0.006 -19.643 0.001 FOS::JUN MA0099.2 Basic leucine zipper factors (bZIP)::Basic leucine zipper factors (bZIP) Fos-related factors::Jun-related factors vertebrates 9.193 0.405 1432 248 1492 188 4176 0.016 4988 0.019 -30.776 0.001 HOXC12 MA0906.1 Homeo domain factors HOX-related factors vertebrates 14.403 0.356 278 1402 348 1332 340 0.002 425 0.003 -13.722 0.001 TBX21 MA0690.1 T-Box factors TBrain-related factors vertebrates 13.531 0.425 490 1190 576 1104 615 0.003 753 0.004 -15.970 0.001 Gfi1b MA0483.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 13.514 0.415 908 772 1000 680 1611 0.010 2034 0.012 -31.349 0.001 JUNB MA0490.1 Basic leucine zipper factors (bZIP) Jun-related factors vertebrates 13.910 0.457 858 822 951 729 1269 0.008 1542 0.009 -23.211 0.001 Ddit3::Cebpa MA0019.1 Basic leucine zipper factors (bZIP)::Basic leucine zipper factors (bZIP) C/EBP-related::C/EBP-related vertebrates 11.652 0.483 383 1297 464 1216 441 0.003 593 0.004 -21.697 0.001 POU6F2 MA0793.1 Homeo domain factors POU domain factors vertebrates 11.693 0.311 531 1149 620 1060 764 0.004 991 0.005 -22.901 0.001 RORA(var.2) MA0072.1 Nuclear receptors with C4 zinc fingers Thyroid hormone receptor-related factors (NR1) vertebrates 17.425 0.369 75 1605 118 1562 84 0.001 121 0.001 -12.616 0.001 RAX MA0718.1 Homeo domain factors Paired-related HD factors vertebrates 9.540 0.256 921 759 1014 666 2210 0.012 2757 0.015 -33.249 0.001 ISX MA0654.1 Homeo domain factors Paired-related HD factors vertebrates 10.591 0.200 944 736 1037 643 2163 0.009 2678 0.012 -28.364 0.000 VENTX MA0724.1 Homeo domain factors NK-related factors vertebrates 11.046 0.353 843 837 938 742 1738 0.008 2235 0.011 -31.761 0.000 Mecom MA0029.1 C2H2 zinc finger factors Factors with multiple dispersed zinc fingers vertebrates 17.909 0.280 44 1636 79 1601 47 0.000 83 0.001 -14.814 0.000 RORA MA0071.1 Nuclear receptors with C4 zinc fingers Thyroid hormone receptor-related factors (NR1) vertebrates 13.190 0.424 492 1188 581 1099 606 0.003 781 0.004 -19.878 0.000 Six3 MA0631.1 Homeo domain factors HD-SINE factors vertebrates 15.078 0.407 19 1661 44 1636 19 0.000 50 0.000 -18.105 0.000 MEOX1 MA0661.1 Homeo domain factors HOX-related factors vertebrates 9.622 0.316 923 757 1018 662 1811 0.010 2120 0.011 -21.397 0.000 PDX1 MA0132.2 Homeo domain factors HOX-related factors vertebrates 9.911 0.238 989 691 1083 597 2729 0.012 3493 0.015 -36.900 0.000 PHOX2A MA0713.1 Homeo domain factors Paired-related HD factors vertebrates 12.067 0.175 349 1331 431 1249 544 0.003 723 0.004 -22.161 0.000 JUND MA0491.1 Basic leucine zipper factors (bZIP) Jun-related factors vertebrates 14.728 0.436 718 962 815 865 955 0.006 1250 0.007 -27.819 0.000 Hoxa11 MA0911.1 Homeo domain factors HOX-related factors vertebrates 11.443 0.370 312 1368 391 1289 400 0.003 490 0.003 -14.138 0.000 NKX2-3 MA0672.1 Homeo domain factors NK-related factors vertebrates 10.899 0.485 1501 179 1557 123 3976 0.022 4816 0.026 -38.861 0.000 HOXC11 MA0651.1 Homeo domain factors HOX-related factors vertebrates 12.647 0.358 374 1306 460 1220 501 0.003 621 0.004 -16.034 0.000 USF1 MA0093.2 Basic helix-loop-helix factors (bHLH) bHLH-ZIP factors vertebrates 13.398 0.578 992 688 1089 591 1523 0.009 1878 0.011 -27.373 0.000 GBX2 MA0890.1 Homeo domain factors HOX-related factors vertebrates 10.020 0.296 1009 671 1106 574 2286 0.012 2778 0.015 -29.802 0.000 CEBPA MA0102.3 Basic leucine zipper factors (bZIP) C/EBP-related vertebrates 13.338 0.344 943 737 1042 638 1758 0.010 2153 0.013 -28.471 0.000 FLI1 MA0475.2 Tryptophan cluster factors Ets-related factors vertebrates 13.279 0.533 1084 596 1180 500 1741 0.009 2214 0.012 -32.033 0.000 LIN54 MA0619.1 CRC domain - vertebrates 11.299 0.189 885 795 988 692 2180 0.011 2683 0.013 -29.379 0.000 PROP1 MA0715.1 Homeo domain factors Paired-related HD factors vertebrates 15.122 0.084 164 1516 231 1449 212 0.001 303 0.002 -17.381 0.000 ETV1 MA0761.1 Tryptophan cluster factors Ets-related factors vertebrates 10.759 0.530 1039 641 1139 541 1654 0.009 2151 0.012 -34.137 0.000 ETV2 MA0762.1 Tryptophan cluster factors Ets-related factors vertebrates 14.664 0.452 336 1344 424 1256 373 0.002 507 0.003 -19.798 0.000 Phox2b MA0681.1 Homeo domain factors Paired-related HD factors vertebrates 13.021 0.174 378 1302 470 1210 623 0.004 797 0.005 -20.526 0.000 MEF2C MA0497.1 MADS box factors Regulators of differentiation vertebrates 14.023 0.282 588 1092 692 988 974 0.008 1487 0.012 -51.886 0.000 Arntl MA0603.1 Basic helix-loop-helix factors (bHLH) PAS domain factors vertebrates 11.029 0.583 739 941 846 834 1047 0.006 1233 0.007 -16.848 0.000 MLXIPL MA0664.1 Basic helix-loop-helix factors (bHLH) bHLH-ZIP factors vertebrates 12.730 0.511 327 1353 416 1264 373 0.002 512 0.003 -19.482 0.000 Foxj3 MA0851.1 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 13.311 0.330 204 1476 280 1400 245 0.002 360 0.003 -25.062 0.000 FEV MA0156.2 Tryptophan cluster factors Ets-related factors vertebrates 11.713 0.519 1105 575 1206 474 1818 0.010 2324 0.013 -33.455 0.000 HOXB13 MA0901.1 Homeo domain factors HOX-related factors vertebrates 12.254 0.281 738 942 848 832 1380 0.007 1891 0.010 -37.398 0.000 EMX2 MA0886.1 Homeo domain factors NK-related factors vertebrates 10.283 0.288 1033 647 1139 541 2565 0.014 3233 0.018 -37.542 0.000 DUX4 MA0468.1 Homeo domain factors Paired-related HD factors vertebrates 15.012 0.238 667 1013 777 903 1129 0.007 1563 0.009 -36.624 0.000 CLOCK MA0819.1 Basic helix-loop-helix factors (bHLH) PAS domain factors vertebrates 11.902 0.508 434 1246 535 1145 530 0.003 689 0.004 -19.224 0.000 EOMES MA0800.1 T-Box factors TBrain-related factors vertebrates 12.412 0.416 350 1330 446 1234 415 0.003 545 0.004 -20.149 0.000 HOXD13 MA0909.1 Homeo domain factors HOX-related factors vertebrates 12.209 0.267 837 843 950 730 1759 0.010 2456 0.013 -44.826 0.000 HOXA13 MA0650.1 Homeo domain factors HOX-related factors vertebrates 11.356 0.282 676 1004 790 890 1213 0.007 1616 0.009 -31.886 0.000 Foxd3 MA0041.1 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 12.945 0.223 638 1042 752 928 1270 0.008 1833 0.012 -45.876 0.000 FOSL2 MA0478.1 Basic leucine zipper factors (bZIP) Fos-related factors vertebrates 14.013 0.477 879 801 994 686 1324 0.008 1642 0.010 -26.204 0.000 VSX2 MA0726.1 Homeo domain factors Paired-related HD factors vertebrates 9.179 0.207 751 929 867 813 1507 0.007 1980 0.009 -30.240 0.000 NKX3-2 MA0122.2 Homeo domain factors NK-related factors vertebrates 10.208 0.421 1141 539 1247 433 2246 0.011 2714 0.013 -27.185 0.000 FOXP1 MA0481.1 Fork head / winged helix factors Forkhead box (FOX) factors vertebrates 14.261 0.301 497 1183 607 1073 756 0.006 1065 0.009 -36.874 0.000 TFEB MA0692.1 Basic helix-loop-helix factors (bHLH) bHLH-ZIP factors vertebrates 11.336 0.533 896 784 1013 667 1328 0.007 1672 0.009 -26.771 0.000 HOXD11 MA0908.1 Homeo domain factors HOX-related factors vertebrates 12.370 0.321 424 1256 532 1148 581 0.003 795 0.004 -24.086 0.000 MNT MA0825.1 Basic helix-loop-helix factors (bHLH) bHLH-ZIP factors vertebrates 11.166 0.600 1001 679 1118 562 1649 0.009 1945 0.011 -21.387 0.000 TFE3 MA0831.1 Basic helix-loop-helix factors (bHLH) bHLH-ZIP factors vertebrates 9.435 0.570 1331 349 1424 256 2824 0.015 3285 0.018 -25.728 0.000 Nr5a2 MA0505.1 Nuclear receptors with C4 zinc fingers FTZ-F1-related receptors (NR5) vertebrates 14.913 0.522 272 1408 368 1312 305 0.002 422 0.003 -22.127 0.000 SREBF2 MA0596.1 Basic helix-loop-helix factors (bHLH) bHLH-ZIP factors vertebrates 13.554 0.540 676 1004 800 880 899 0.005 1177 0.006 -25.746 0.000 TFEC MA0871.1 Basic helix-loop-helix factors (bHLH) bHLH-ZIP factors vertebrates 10.541 0.520 925 755 1048 632 1402 0.008 1782 0.010 -28.652 0.000 CEBPG MA0838.1 Basic leucine zipper factors (bZIP) C/EBP-related vertebrates 14.660 0.434 302 1378 404 1276 353 0.002 496 0.003 -20.361 0.000 Mycn MA0104.3 Basic helix-loop-helix factors (bHLH) bHLH-ZIP factors vertebrates 13.008 0.673 1173 507 1285 395 2200 0.010 2617 0.011 -23.239 0.000 HOXC10 MA0905.1 Homeo domain factors HOX-related factors vertebrates 11.056 0.327 820 860 947 733 1707 0.009 2241 0.012 -35.941 0.000 CEBPB MA0466.2 Basic leucine zipper factors (bZIP) C/EBP-related vertebrates 12.768 0.434 743 937 871 809 1172 0.006 1520 0.008 -28.387 0.000 CEBPE MA0837.1 Basic leucine zipper factors (bZIP) C/EBP-related vertebrates 11.682 0.433 720 960 848 832 1121 0.006 1471 0.008 -29.016 0.000 Nkx3-1 MA0124.2 Homeo domain factors NK-related factors vertebrates 11.264 0.422 1065 615 1187 493 1891 0.009 2341 0.011 -28.113 0.000 HESX1 MA0894.1 Homeo domain factors Paired-related HD factors vertebrates 10.744 0.273 797 883 929 751 1647 0.009 2113 0.011 -32.293 0.000 Srebf1(var.2) MA0829.1 Basic helix-loop-helix factors (bHLH) bHLH-ZIP factors vertebrates 14.940 0.492 332 1348 444 1236 374 0.002 542 0.003 -22.882 0.000 Rarg MA0859.1 Nuclear receptors with C4 zinc fingers Thyroid hormone receptor-related factors (NR1) vertebrates 24.722 0.472 24 1656 67 1613 25 0.000 70 0.001 -21.544 0.000 ELF3 MA0640.1 Tryptophan cluster factors Ets-related factors vertebrates 17.342 0.584 88 1592 159 1521 95 0.001 175 0.001 -21.842 0.000 MEF2A MA0052.3 MADS box factors Regulators of differentiation vertebrates 17.141 0.234 321 1359 439 1241 391 0.003 665 0.004 -36.918 0.000 YY2 MA0748.1 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 11.703 0.548 405 1275 536 1144 477 0.003 672 0.004 -25.031 0.000 Esrrg MA0643.1 Nuclear receptors with C4 zinc fingers Steroid hormone receptors (NR3) vertebrates 13.141 0.453 930 750 1074 606 1479 0.008 1834 0.010 -26.393 0.000 Arid5a MA0602.1 ARID domain factors ARID-related factors vertebrates 10.369 0.277 274 1406 393 1287 344 0.003 568 0.004 -35.275 0.000 ETV3 MA0763.1 Tryptophan cluster factors Ets-related factors vertebrates 11.632 0.531 538 1142 684 996 620 0.003 974 0.005 -35.999 0.000 Zfx MA0146.2 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 13.122 0.749 1343 337 1456 224 4584 0.035 5183 0.039 -31.857 0.000 SREBF2(var.2) MA0828.1 Basic helix-loop-helix factors (bHLH) bHLH-ZIP factors vertebrates 15.418 0.490 343 1337 477 1203 386 0.002 596 0.003 -27.275 0.000 ERF MA0760.1 Tryptophan cluster factors Ets-related factors vertebrates 12.896 0.540 486 1194 640 1040 572 0.003 893 0.005 -34.084 0.000 CEBPD MA0836.1 Basic leucine zipper factors (bZIP) C/EBP-related vertebrates 13.212 0.426 587 1093 747 933 832 0.005 1177 0.006 -31.940 0.000 CREB1 MA0018.2 Basic leucine zipper factors (bZIP) CREB-related factors vertebrates 10.139 0.523 804 876 969 711 1121 0.005 1504 0.007 -28.064 0.000 ELF1 MA0473.2 Tryptophan cluster factors Ets-related factors vertebrates 16.243 0.536 200 1480 320 1360 216 0.001 382 0.002 -29.485 0.000 PAX5 MA0014.2 Paired box factors Paired domain only vertebrates 13.609 0.583 475 1205 634 1046 574 0.006 861 0.009 -42.867 0.000 MEF2B MA0660.1 MADS box factors Regulators of differentiation vertebrates 18.372 0.260 191 1489 312 1368 214 0.001 394 0.003 -31.480 0.000 Nr2f6(var.2) MA0728.1 Nuclear receptors with C4 zinc fingers RXR-related receptors (NR2) vertebrates 25.042 0.463 16 1664 67 1613 16 0.000 70 0.001 -25.027 0.000 MEF2D MA0773.1 MADS box factors Regulators of differentiation vertebrates 18.499 0.228 268 1412 406 1274 321 0.002 595 0.004 -39.017 0.000 ELF4 MA0641.1 Tryptophan cluster factors Ets-related factors vertebrates 16.253 0.606 126 1554 233 1447 134 0.001 280 0.002 -30.276 0.000 YY1 MA0095.2 C2H2 zinc finger factors More than 3 adjacent zinc finger factors vertebrates 14.365 0.526 480 1200 649 1031 586 0.004 849 0.006 -31.390 0.000 MLX MA0663.1 Basic helix-loop-helix factors (bHLH) bHLH-ZIP factors vertebrates 14.721 0.547 209 1471 342 1338 223 0.001 400 0.002 -28.042 0.000 NR2F1 MA0017.2 Nuclear receptors with C4 zinc fingers RXR-related receptors (NR2) vertebrates 13.343 0.589 713 967 896 784 972 0.007 1367 0.010 -38.752 0.000 EHF MA0598.2 Tryptophan cluster factors Ets-related factors vertebrates 14.797 0.591 139 1541 256 1424 146 0.001 297 0.002 -30.406 0.000 ELK1 MA0028.2 Tryptophan cluster factors Ets-related factors vertebrates 14.316 0.561 557 1123 743 937 684 0.004 1118 0.006 -41.206 0.000 ELK3 MA0759.1 Tryptophan cluster factors Ets-related factors vertebrates 11.791 0.539 662 1018 866 814 866 0.005 1352 0.007 -41.990 0.000 HIC2 MA0738.1 C2H2 zinc finger factors Factors with multiple dispersed zinc fingers vertebrates 8.457 0.634 1680 0 1680 0 15797 0.077 15207 0.074 14.774 0.000 SOX8 MA0868.1 High-mobility group (HMG) domain factors SOX-related factors vertebrates 28.805 0.342 0 1680 1 1679 0 0.000 1 0.000 -4.126 0.000